Preheat your oven to 350F and move the rack to the top third of the oven. Take the salmon out of the fridge to let it come to room temperature while you're prepping the recipe ingredients.
Meanwhile, add the mayo, lemon juice, Tony's seasoning, garlic powder, and onion powder to a bowl. Stir until smooth, then add in the crab meat, panko, parmesan cheese, and parsley, and gently combine.
Place the salmon fillets on a foil-lined baking sheet. Make a cut lengthwise down each piece of salmon, being careful to stop before you cut the skin or get too close to the edges.
Spoon 1/4 of the crab mixture into each "pocket", gently packing it down. Some will spill over on top of the salmon, and that's totally fine.
Bake, uncovered, for 20 minutes, and then broil for a few minutes to brown the topping (watch it carefully so it doesn't burn). If the salmon is closer to 2" thick, cook for 25 minutes prior to broiling.